50-157-1286
CD3E Recombinant Rabbit Monoclonal Antibody (BL-298-5D12), Bethyl Laboratories
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-1286-Each-of-1 | In Stock | ₹ 12,998.45 |
50-157-1286 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,998.45
GST (18%): ₹ 2,339.721
Total Price: ₹ 15,338.171
Antigen
CD3E
Classification
Recombinant Monoclonal
Conjugate
Unconjugated
Gene
CD3E
Gene Alias
FLJ18683; T3E; TCRE; CD3-epsilon; CD3e antigen; epsilon polypeptide TiT3 complex; T-cell antigen receptor complex; epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; HCD3
Host Species
Rabbit
Purification Method
Purified
Regulatory Status
RUO
Gene ID (Entrez)
916
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
BL-298-5D12
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene Accession No.
P07766
Gene Symbols
CD3E
Immunogen
Between 157 and 207
Quantity
10 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex
- T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta
- These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11
- The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits
- CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation
- The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum
- It is never expressed on B or NK cells
- Decreased percentages of T lymphocytes may be observed in some autoimmune diseases
- The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11
- Defects in the CD3 gene are associated with CD3 immunodeficiency.