50-157-1279
Phospho-KAP-1 (Ser824) Recombinant Rabbit Monoclonal Antibody (BL-246-7B5), Bethyl Laboratories
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-1279-Each-of-1 | In Stock | ₹ 31,319.10 |
50-157-1279 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,319.10
GST (18%): ₹ 5,637.438
Total Price: ₹ 36,956.538
Antigen
Phospho-KAP-1 (Ser824)
Classification
Recombinant Monoclonal
Conjugate
Unconjugated
Gene
TRIM28
Gene Alias
Transcription intermediary factor 1-beta, Tripartite motif protein 28, Nuclear corepressor KAP-1, KRAB-associated protein 1, KAP-1, KRAB-interacting p
Host Species
Rabbit
Purification Method
Purified
Regulatory Status
RUO
Gene ID (Entrez)
10155
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
BL-246-7B5
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene Accession No.
Q13263
Gene Symbols
TRIM28
Immunogen
Surrounding serine 824
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For ICC, formaldehyde fixation is recommended
- Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells
- For IHC, epitope retrieval with c The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors
- There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome
- These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1)
- KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger
- KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression
- KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1)
- KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression
- Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.