50-157-1434
KAP-1 Polyclonal Antibody, Bethyl Laboratories
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-1434-Each-of-1 | In Stock | ₹ 12,384.35 |
50-157-1434 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,384.35
GST (18%): ₹ 2,229.183
Total Price: ₹ 14,613.533
Antigen
KAP-1
Classification
Polyclonal
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.
Q13263
Gene Symbols
TRIM28
Immunogen
Between 1 and 50
Quantity
10 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Conjugate
Unconjugated
Gene
TRIM28
Gene Alias
Transcription intermediary factor 1-beta, Tripartite motif protein 28, Nuclear corepressor KAP-1, KRAB-associated protein 1, KAP-1, KRAB-interacting p
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10155
Content And Storage
4° C
Form
Liquid
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Chinese hamster The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors
- There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome
- These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1)
- KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger
- KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression
- KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1)
- KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression
- Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.