50-166-2201
WWTR1 Mouse anti-Human, Clone: OTI1H9, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-2201-Each-of-1 | In Stock | ₹ 60,342.00 |
50-166-2201 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 60,342.00
GST (18%): ₹ 10,861.56
Total Price: ₹ 71,203.56
Antigen
WWTR1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
WWTR1
Gene Alias
TAZ
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25937
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI1H9
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q9GZV5
Gene Symbols
WWTR1
Immunogen
Full length human recombit protein of human WWTR1 produced in HEK293T cell.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
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Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1
- In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation
- WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex
- WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.