CD357 (AITR/GITR) Monoclonal Antibody (eBioAITR), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-167-76-Each | In Stock | ₹ 26,223.85 |
50-167-76 - Each
In Stock
Quantity
1
Base Price: ₹ 26,223.85
GST (18%): ₹ 4,720.293
Total Price: ₹ 30,944.143
Antigen
CD357 (AITR/GITR)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9Y5U5
Gene Symbols
Tnfrsf18
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8784
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
eBioAITR
Conjugate
Alexa Fluor 488
Gene
Tnfrsf18
Gene Alias
Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25 kDa member of the TNFR superfamily
- AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen
- AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC
- At the protein level, AITR is expressed by a small population of activated PBMC
- AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-kappaB activation via TRAF2
- Recently TL6 (AITRL) has been reported as the ligand for AITR
- Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells
- Applications Reported: This eBioAITR antibody has been reported for use in flow cytometric analysis
- Applications Tested: This eBioAITR antibody has been pre-titrated and tested by flow cytometric analysis of PHA-stimulated normal peripheral blood mononuclear cells
- This can be used at 5 μL (0.25 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
- Filtration: 0.2 μm post-manufacturing filtered
- Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene
- It is mapped to 1p36.33
- This gene encodes a member of the TNF-receptor superfamily
- The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells
- Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death
- Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.