50-167-8247
RIPK1 Mouse anti-Human, Clone: OTI2D6, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-8247-Each-of-1 | In Stock | ₹ 44,954.79 |
50-167-8247 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,954.79
GST (18%): ₹ 8,091.862
Total Price: ₹ 53,046.652
Antigen
RIPK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q13546
Gene Symbols
RIPK1
Immunogen
Human recombit protein fragment corresponding to amino acids 133-422 of human RIPK1 produced in E.coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI2D6
Conjugate
Unconjugated
Gene
RIPK1
Gene Alias
RIP, RIP-1, RIP1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8737
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage
- Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor
- Phosphorylates DAB2IP at ′Ser-728′ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade
- Ubiquitination by TRAF2 via ′Lys-63′-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules
- Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation
- Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death
- RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.