50-172-6087
ATG5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-172-6087-Each-of-1 | In Stock | ₹ 44,150.23 |
50-172-6087 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
ATG5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATG5
Gene Alias
APG5, APG5 LIKE, APG5L, Apoptosis specific protein, ASP, ATG5, Autophagy protein 5, hAPG5
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11793, 365601, 9474
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.27 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
Q3MQ06, Q99J83, Q9H1Y0
Gene Symbols
Atg5
Immunogen
ATG5 Fusion Protein Ag0214
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is raised against 28-275 amino acids of human ATG5
- It can recognize the ATG5-ATG12 complex (55 kDa) which can be truncated and generate a 40-45 kDa band
- 10181-2-AP also recognizes the free ATG5 (32 kDa)
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation
- Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole)
- APG5, required for autophagy, conjugates to ATG12 and associates with an isolation membrane to form a cup-shaped isolation membrane and autophagosome
- The conjugate detaches from the membrane immediately before or after autophagosome formation is completed
- APG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton
- Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.