50-172-7795
CREB1 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-172-7795-Each-of-1 | In Stock | ₹ 44,150.23 |
50-172-7795 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
CREB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CREB1
Gene Alias
CREB, CREB 1, CREB1
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12912, 1385, 81646
Content And Storage
-20°C
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Concentration
0.29 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
P15337, P16220, Q01147
Gene Symbols
Creb1
Immunogen
CREB1 Fusion Protein Ag2852
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
- Activation of CREB is dependent upon the phosphorylation of serine 133
- Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
- Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
- CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
- CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
- In humans, the gene is located on the q arm of chromosome 2
- Diseases associated with CREB dysfunction include Alzheimer′s Disease, histiocytoma and soft tissue melanoma.