50-173-0145
PI4K2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-0145-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-0145 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
PI4K2A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PI4K2A
Gene Alias
PI 4-kinase II alpha, PI4K2A, PI4KII, PIK42A, RP11 548K23.6
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114554, 55361, 84095
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
0.13 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q2TBE6, Q99M64, Q9BTU6
Gene Symbols
PI4K2A
Immunogen
PI4K2A Fusion Protein Ag7564
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
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Description
- Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis
- PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs
- PI4K II is activated by detergent and inhibited by adenosine
- Overexpression of PI4KII in COS-7 cells increases synthesis of PtdIns4P
- Some cells overexpressing PI4KII have scattered or no perinuclear Golgi
- Knockdown of PI4KII by RNA interference (RNAi) does not disrupt the Golgi, and some cells show expanded Golgi
- RNAi reduces the Golgi level of PtdIns4P and blocks the association between AP1 and the trans-Golgi network
- PI4KII RNAi had little effect on intra-Golgi trafficking, but it inhibited export to plasma membrane export by 35%
- It has been proposed that PI4KII generates PtdIns4P-rich domains within the Golgi that specify docking of the AP1 coat machinery.