50-173-0975
PHAX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-0975-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-0975 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
PHAX
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PHAX
Gene Alias
PHAX, RNUXA
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
286917, 51808, 56698
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Concentration
0.15 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q63068, Q9H814, Q9JJT9
Gene Symbols
Phax
Immunogen
PHAX Fusion Protein Ag9602
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
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Description
- A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus
- Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other
- Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly
- It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor
- The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
- Its compartmentalized phosphorylation cycle may also contribute to the directionality of export
- Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner
- Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA)
- Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies
- Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs
- Binds also to telomerase RNA.