IL-4 Monoclonal Antibody (B-S4), FITC, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-177-78-Each-of-1 | In Stock | ₹ 25,721.00 |
50-177-78 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,721.00
GST (18%): ₹ 4,629.78
Total Price: ₹ 30,350.78
Antigen
IL-4
Classification
Monoclonal
Concentration
10 μL/Test
Formulation
TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Gene Accession No.
P05112
Gene Symbols
Il4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3565
Content And Storage
4° C, store in dark
Form
Liquid
Applications
Flow Cytometry
Clone
B-S4
Conjugate
FITC
Gene
Il4
Gene Alias
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Description: IL-4 (B-S4) is a mouse monoclonal antibody raised against IL-4 of humanorigin
- BMS129FI is suitable for intracellular staining of IL-4
- Human IL-4 exists in molecular weight forms between 15,000 and 19,000 daltons, representing variable glycosylation
- The gene for human IL-4 is found on the long arm of chromsome 5 in close association with genes for IL-13, IL-5 GM-CSF and IL-3.IL-4 mediates its function by binding to receptors expressed on target cells
- The IL-4 receptors exhibit an affinity of approximately 10-10 M
- Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines
- On T and B cells, receptors are present in low numbers (appr
- 400), which are reported to be up-regulated by IL-2 and IL-4
- IL-4 is produced by a particular subset of T helper cells, the TH2 cells
- These cells tend to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta)
- Apart from T cells, it has been shown that mast cells can produce IL-4
- IL-4 exerts numerous effects on various hematopoietic cell types
- On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression
- Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor
- IL-4 has been found to have the broadest range of actions
- The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13
- STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4
- The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q
- In particular, IL-4 is located in close proximity to IL13 on the chromosome
- Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome
- IL-4 delta 2 is a known splice variant of IL-4.