TLE5/Amino-terminal enhancer of split Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-2202-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-2202 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
TLE5/Amino-terminal enhancer of split
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TLE5
Gene Alias
AES; AES-1; AES-2; AL024115; Amino enhancer of split; Amino-terminal enhancer of split; Esp1; Gp130-associated protein GAM; Grg; GRG5; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; related to Drosophila groucho; R-esp1; TLE family member 5; TLE family member 5, transcriptional modulator; TLE5
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
166
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q08117
Gene Symbols
TLE5
Immunogen
KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading
- Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment
- Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination
- AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis
- It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family
- Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.