GAD67/GAD1 Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-2554-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-2554 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
GAD67/GAD1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GAD1
Gene Alias
67 kDa glutamic acid decarboxylase; BOS_1646; CPSQ1; EP10; FLJ45882; GAD; GAD 1; GAD 67; Gad1; Gad-1; GAD25; GAD44; GAD67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 2; Glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase 1; LOC100344727; OTTHUMP00000041055; SCP
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2571
Content And Storage
-20°C
Form
Liquid
Applications
ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q99259
Gene Symbols
GAD1
Immunogen
KLH conjugated synthetic peptide derived from human GAD67.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid
- Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell
- GAD-67 is responsible for the basal levels of GABA synthesis
- In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production
- The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal
- Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.