Phospho-ALK (Tyr1278, Tyr1282, Tyr1283) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5089-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5089 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-ALK (Tyr1278, Tyr1282, Tyr1283)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ALK
Gene Alias
ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; p80; Tcrz; TFG/ALK
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
238
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q9UM73
Gene Symbols
ALK
Immunogen
KLH conjugated synthetic phosphopeptide derived from human ALK around the phosphorylation site of Tyr1278/1282/1283.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas
- The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3′ half of ALK, derived from chromosome 2, is fused to the 5′ portion of NPM from chromosome 5
- A recent study shows that the product of the NPM-ALK fusion gene is oncogenic
- The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain
- These sequences are absent in the product of the transforming NPM-ALK gene
- ALK shows the greatest sequence similarity to LTK
- ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.