Phospho-CBL2 (Tyr774) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5136-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5136 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-CBL2 (Tyr774)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cbl
Gene Alias
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Casitas B-lineage lymphoma proto-oncogene; Cbl; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; C-CBL; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; Proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; Signal transduction protein CBL
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
867
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
P22681
Gene Symbols
Cbl
Immunogen
KLH conjugated synthetic phosphopeptide derived from human CBL2 around the phosphorylation site of Tyr774.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation
- Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed)
- Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation
- Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.