Phospho-TBK1 (Ser172) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5402-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5402 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-TBK1 (Ser172)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TBK1
Gene Alias
1200008B05Rik; AI462036; AW048562; BOS_5439; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
29110
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q9UHD2
Gene Symbols
TBK1
Immunogen
KLH conjugated synthetic phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- Nuclear factor kappa B (NF-KB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity
- Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB
- The IKK complex contains IKKa, IKKß, and IKKK
- A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K
- NAK/TBK1 activates IKKß through direct phosphorylation
- NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors
- NAK/TBK1 functions upstream of NIK and the IKK complex
- NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.