Wnt1 Monoclonal Antibody (13F9), Rockland™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-0555-Each-of-1 | In Stock | ₹ 53,980.28 |
50-199-0555 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,980.28
GST (18%): ₹ 9,716.45
Total Price: ₹ 63,696.73
Antigen
Wnt1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P04628
Gene Symbols
WNT1
Immunogen
Synthetic peptide corresponding to an internal region of human Wnt1 protein.
Regulatory Status
RUO
Gene ID (Entrez)
7471
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunoprecipitation, Western Blot
Clone
13F9
Conjugate
Unconjugated
Gene
WNT1
Gene Alias
BMND16; INT1; Int-1; OI15; Proto-oncogene Int-1; Proto-oncogene Int-1 homolog; proto-oncogene protein Wnt-1; Proto-oncogene Wnt-1; sw; swaying; wingless-related MMTV integration site 1; Wingless-type MMTV integration site 1 homolog; Wingless-type MMTV integration site 1, homolog; wingless-type MMTV integration site family member 1; wingless-type MMTV integration site family, member 1; wingless-type MMTV integration site family, member 1 (oncogene INT1); Wnt family member 1; WNT1; Wnt-1
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody reacts with human and mouse Wnt1 protein
- A BLAST analysis was used to suggest cross-reactivity with Wnt1 from mouse, human, rat, bovine, dog, macaque, opossum and rat based on a 100% homology with the immunizing sequence
- Partial cross-reactivity is expected against chicken Wnt1 based on a 91% sequence homology
- Cross-reactivity with Wnt1 from other sources has not been determined
- Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal
- The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade
- Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor
- Extensive research has shown that deregulation of these pathways or its components can lead to cancer
- Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form
- At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1
- Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways
- Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis
- Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.