Phospho-Huntington (Ser421)Rabbit anti-Human, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1744-Each-of-1 | In Stock | ₹ 52,930.08 |
50-199-1744 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,930.08
GST (18%): ₹ 9,527.414
Total Price: ₹ 62,457.494
Antigen
Phospho-Huntington (Ser421)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Htt
Gene Alias
AI256365; C430023I11Rik; HD; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog; IT15; SLC6A4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
3064
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
0.96 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P42858
Gene Symbols
Htt
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody is specific for phosphorylated human Huntington protein at the pS421 residue
- BLAST analysis indicates 100 % homology of the immunizing sequence with Huntington homologues from chimpanzee, pig and chicken
- Cross reactivity with Huntington protein homologues from mouse and rat may also occur as sequence homology varies by one amino acid residue in this sequence
- Reactivity with Huntington protein from other sources is not known
- Minimal reactivity is expected with the non-phosphorylated form of the protein
- Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons
- This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
- HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons
- The huntingtin gene is widely expressed and is required for normal development
- It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues
- The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed
- The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.