Wnt1Rabbit anti-Bovine, Canine, Human, Marsupial, Mouse, Rat, Rhesus Monkey, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1925-Each-of-1 | In Stock | ₹ 52,930.08 |
50-199-1925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,930.08
GST (18%): ₹ 9,527.414
Total Price: ₹ 62,457.494
Antigen
Wnt1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
WNT1
Gene Alias
BMND16; INT1; Int-1; OI15; Proto-oncogene Int-1; Proto-oncogene Int-1 homolog; proto-oncogene protein Wnt-1; Proto-oncogene Wnt-1; sw; swaying; wingless-related MMTV integration site 1; Wingless-type MMTV integration site 1 homolog; Wingless-type MMTV integration site 1, homolog; wingless-type MMTV integration site family member 1; wingless-type MMTV integration site family, member 1; wingless-type MMTV integration site family, member 1 (oncogene INT1); Wnt family member 1; WNT1; Wnt-1
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
22408, 24881, 486560, 540662, 709009, 7471
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P04426, P04628
Gene Symbols
WNT1
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Canine, Human, Marsupial, Mouse, Rat, Rhesus Monkey
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody reacts with human and mouse Wnt1 protein
- A BLAST analysis was used to suggest cross-reactivity with Wnt1 from mouse, human, rat, bovine, dog, macaque, and opossum based on a 100% homology with the immunizing sequence
- Partial cross-reactivity is expected against chicken Wnt1 based on a 91% sequence homology
- Cross-reactivity with Wnt1 from other sources has not been determined
- Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal
- The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade
- Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor
- Extensive research has shown that deregulation of these pathways or its components can lead to cancer
- Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form
- At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1
- Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways
- Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis
- Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.