CD209a Monoclonal Antibody (MMD3), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-209-482-Each-of-1 | In Stock | ₹ 33,998.00 |
50-209-482 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,998.00
GST (18%): ₹ 6,119.64
Total Price: ₹ 40,117.64
Antigen
CD209a
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q91ZX1
Gene Symbols
Cd209a
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
170786
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Frozen)
Clone
MMD3
Conjugate
eFluor 660
Gene
Cd209a
Gene Alias
CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; Cd209a; CD209a antigen; CD209a molecule; Cd209d; CD209d antigen; CDSIGN; Cire; CLEC4L; Clec4m; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; C-type lectin domain family 4, member M; Dcsign; DC-SIGN; DC-SIGN1; Dc-signr; DC-SIGN-related protein; Dendritic cell-specific ICAM-3-grabbing non-integrin; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965; MGC130443; RGD1561104; SIGN-R1; SIGNR5
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2c κ
Related Products
Description
- This MMD3 MAb recognizes mouse CD209a, which is also known as DC-SIGN
- CD209a is a type II transmembrane C-type lectin expressed on a subset of dendritic cells, including some CD4+, CD8- and plasmacytoid pre-dendritic cells
- Studies indicate that CD209a expression can vary according to the activation state of the host
- Moreover, CD209a is down-regulated in spleen-derived dendritic cell cultures supplemented with GM-CSF
- CD209a is involved in mediating the innate immune response by binding microbial carbohydrates
- Cross-blocking studies suggest that MMD3 recognizes a different a different epitope from LWC06 and 5H10
- This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages
- The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health
- The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain
- The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells
- The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity
- Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability
- This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN)
- DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution
- Alternative splicing results in multiple variants.