50-245-631
IL-9 Monoclonal Antibody (D9302C12), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-245-631-Each-of-1 | In Stock | ₹ 37,825.00 |
50-245-631 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
IL-9
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P15247
Gene Symbols
Il9
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16198
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay, Neutralization
Clone
D9302C12
Conjugate
Functional Grade
Gene
Il9
Gene Alias
cytokine P40; homolog of mouse T cell and mast cell growth factor 40; HP40; IL9; IL-9; ILN; Interleukin; interleukin 9; Interleukin9; interleukin-9; P40; p40 cytokine; p40 T-cell and mast cell growth factor; T-cell growth factor P40
Host Species
Armenian Hamster
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
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Description
- Description: This monoclonal D9302C12 antibody reacts with and inhibits the bioactivity of mouse IL-9
- IL-9 is a 14 kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations
- The receptor, which is a heterodimer of the gamma chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand
- Since the discovery of IL-9, numerous other functions have been observed
- It induces Th17 and Treg differentiation in CD4+ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells
- IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells
- Th9 cells, a newly discovered subset of CD4+ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10
- Th9 development is induced by stimulation of undifferentiated CD4+ with IL-4 and TGF beta
- Th2 cells can also be driven towards a Th9 phenotype in the presence of TGF beta
- Applications Reported: The D9302C12 antibody inhibits the bioactivity of mouse IL-9
- Applications Tested: The ND50 of D9302C12, as measured by the inhibition TS-1 cell proliferation, is less than or equal to 500 ng/mL in the presence of 0.1 ng/mL of Mouse IL-9 Recombit Protein
- Neutralization dose will vary depending on assay method, cytokine concentration, and cell type
- This antibody should be carefully titrated for optimal performance in the assay of interest
- Interleukin 9 (IL-9) is produced by activated T helper 2 (Th2) lymphocytes
- IL-9 regulates many cell types involved in classical Th2-associated asthma responses, including B and T lymphocytes, mast cells, eosinophils, and epithelial cells
- The mouse IL-9 cDNA encodes a 144 amino acid precursor protein with an 18 amino acid signal peptide that is cleaved to form the mature cysteine-rich protein with a molecular mass of 14 kDa
- Native mouse IL-9 is heavily glycosylated
- Recently, TGF beta has been reported to play an important role in the differentiation of IL-17-producing T helper cells and inducible regulatory T cells by reprogramming Th2 cells to secrete IL-9, thereby driving the differentiation of Th9 cells directly.