50-245-736
CD150 Monoclonal Antibody (mShad150), PE-Cyanine7, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-245-736-Each-of-1 | In Stock | ₹ 37,736.00 |
50-245-736 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,736.00
GST (18%): ₹ 6,792.48
Total Price: ₹ 44,528.48
Antigen
CD150
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9QUM4
Gene Symbols
Slamf1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27218
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
mShad150
Conjugate
PE-Cyanine7
Gene
Slamf1
Gene Alias
4933415F16; AA177906; CD150; CD150 antigen; CDw150; ESTM51; IPO-3; RGD1560634; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule; signaling lymphocytic activation molecule family member 1; Slam; SLAM family member 1; Slamf1
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b λ
Related Products
Description
- Description: The mShad150 monoclonal antibody reacts with mouse CD150, an ∽70 kDa transmembrane glycoprotein also known as Signaling Lymphocyte Activation Molecule (SLAM)
- CD150 is expressed by T cells, in particular Th1, and B cells; this expression is rapidly upregulated upon activation
- Immature thymocytes and dendritic cells also express this antigen
- Signaling through SLAM in T cells induces proliferation and augmentation of the interferon-gamma response
- Furthermore, SLAM is thought to play a role in adhesion between the T cell and antigen-presenting cell
- The mShad150 antibody has been reported to also stain the CD150+CD244-CD48-CD41- population of pluripotent hematopoietic stem cells
- Applications Reported: This mShad150 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This mShad150 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Light sensitivity: This tandem dye is sensitive photo-induced oxidation
- Please protect this vial and stained samples from light
- CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation
- SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation
- Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM
- It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells
- Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells
- Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain
- Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).