Glucocorticoid Receptor Monoclonal Antibody, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-255-0799-Each | In Stock | ₹ 32,542.85 |
50-255-0799 - Each
In Stock
Quantity
1
Base Price: ₹ 32,542.85
GST (18%): ₹ 5,857.713
Total Price: ₹ 38,400.563
Antigen
Glucocorticoid Receptor
Classification
Monoclonal
Conjugate
Unconjugated
Gene
Nr3c1
Gene Alias
cytosolic/nuclear receptor, fb13f09, GCCR, Gcr, GCRST, glucocorticoid nuclear receptor variant 1, glucocorticoid receptor, glucocorticoid receptor 1, glucocorticoid receptor alpha, GR, gr alpha, GR Kit, Grl, Grl1, Grl-1, Nr3c1, Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3, group C, member 1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), OTTHUMP00000222854, OTTHUMP00000222858, utouto, utut, wu:fb13f09, zgc:113038
Host Species
Mouse
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
24413, 2908
Content And Storage
-20°, C, Avoid Freeze/Thaw Cycles
Isotype
IgG2b κ
Applications
ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
Concentration
1 mg/mL
Formulation
antibody with <0.1% thimerosal
Gene Accession No.
P04150, P06536
Gene Symbols
Nr3c1
Immunogen
Raised against the aa 304-428 of human glucocorticoid receptor.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Form
Liquid
Related Products
Description
- Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors
- Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins
- The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus
- Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart
- Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined
- Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance
- Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation
- GR binds to known steroids such as dexamethasone with nanomolar affinity