LXR alpha Recombinant Rabbit Monoclonal Antibody (12H21L12), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-343-0-Each-of-1 | In Stock | ₹ 38,270.00 |
70-343-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,270.00
GST (18%): ₹ 6,888.60
Total Price: ₹ 45,158.60
Antigen
LXR alpha
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.4
Gene Accession No.
Q13133, Q9Z0Y9
Gene Symbols
NR1H3
Immunogen
Peptides corresponding to human LXR alpha [1) aa71-aa88 2) aa317-aa330 3) aa177-aa195]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
12H21L12
Conjugate
Unconjugated
Gene
NR1H3
Gene Alias
AU018371, liver X nuclear receptor alpha variant 1, liver X receptor alpha, LXR, LXR alpha, Lxra, LXR-a, LXRalpha, LXRb, NER, NERI, NR1H2, Nr1h3, nuclear orphan receptor LXR-alpha, nuclear oxysterol receptor LxR-alpha, nuclear receptor subfamily 1 group H member 3, nuclear receptor subfamily 1, group H, member 3, oxysterols receptor LXR-alpha, RLD1, RLD-1, ubiquitously-expressed nuclear receptor 1, Unr1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10062, 22259
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Rat, Bovine
- NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity
- Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES
- LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides
- NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8
- It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.