ErbB4 (Her4) Monoclonal Antibody (HFR1), Biotin, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-255-0889-Each | In Stock | ₹ 32,809.85 |
50-255-0889 - Each
In Stock
Quantity
1
Base Price: ₹ 32,809.85
GST (18%): ₹ 5,905.773
Total Price: ₹ 38,715.623
Antigen
ErbB4 (Her4)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.
Q15303, Q61527
Gene Symbols
ERBB4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13869, 2066
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Isotype
IgG2b κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
HFR1
Conjugate
Biotin
Gene
ERBB4
Gene Alias
4ICD, ALS19, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, avian erythroblastosis oncogene B 4, c-erbB-4, erb-b2 receptor tyrosine kinase 4, Erbb4, ERBB4 intracellular domain, ERBB4 transcript variant I12DEL, ERBB4 transcript variant I20DEL, Her4, human epidermal growth factor receptor 4, Mer4, OTTHUMP00000209432, p180erbB4, proto-oncogene-like protein c-ErbB-4, receptor tyrosine kinase, receptor tyrosine-protein kinase erbB-4, s80HER4, Tyro-2, Tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), v-erb-b2 avian erythroblastic leukemia viral oncogene 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Liquid
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Description
- Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3
- ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation
- ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases)
- ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself
- Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation
- ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum
- Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361
- Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3
- ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.