50-271-8662
IL18BP Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-271-8662-Each-of-1 | In Stock | ₹ 1,75,552.50 |
50-271-8662 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,75,552.50
GST (18%): ₹ 31,599.45
Total Price: ₹ 2,07,151.95
Antigen
IL18BP
Classification
Polyclonal
Conjugate
Biotin
Gene
IL18BP
Gene Alias
Igifbp; Il18bp; IL-18BP; IL18BPa; interferon gamma inducing factor binding protein; interferon gamma-inducing factor-binding protein; interleukin 18 binding protein; interleukin-18 binding protein; interleukin-18-binding protein; MC51L-53L-54L homolog gene product; MC54L; Tadekinig-alfa
Host Species
Goat
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16068
Content And Storage
-20°C
Isotype
IgG
Applications
Western Blot, ELISA
Concentration
0.1-1.0 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q9Z0M9
Gene Symbols
IL18BP
Immunogen
E.coli-derived Recombinant Murine IL-18BP
Quantity
500μg
Primary or Secondary
Primary
Target Species
Mouse
Form
Lyophilized
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Description
- Preparation: Produced from sera of goats immunized with highly pure Recombinant Murine IL-18BP
- Anti-Murine IL-18BP-specific antibody was purified by affinity chromatography and then biotinylated
- Sandwich ELISA: To detect Murine IL-18BP by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required
- This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Murine IL-18BP (500-P153G) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Murine IL-18BP
- Western Blot: To detect mIL-18BP by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
- Used in conjunction with compatible secondary reagents the detection limit for Recombinant mIL-18BP is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
- 500-P153GBT-1MG will be provided as 2 x 500 μg Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors
- Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity
- As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to a variety of diseases, including eczema, asthma, and the autoimmune condition, Crohn's disease
- The upregulation of IL-18BP by keratinocytes expressing the human papillomavirus (HPV) E7 oncoprotein has been shown to decrease IL-18-induced IFN-gamma production and IL-18-mediated T cell activation
- Elevated levels of IL-18 and IL-18BP, as well as proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta and IL-8, have been linked to chronic inflammation and observed in macrophages (including Kupffer cells) isolated from lesions and intestinal tissues of Crohn's disease patients
- As a member of the immunoglobulin-like class of receptors, IL-18BP contains a single immunoglobulin (Ig) domain; although two (b and d) of the four identified human isoforms (a-d) contain incomplete domains that greatly reduce their binding affinity.