GPNMB Monoclonal Antibody (CTSREVL), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-570-880-Each-of-1 | In Stock | ₹ 12,549.00 |
50-570-880 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,549.00
GST (18%): ₹ 2,258.82
Total Price: ₹ 14,807.82
Antigen
GPNMB
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q99P91
Gene Symbols
GPNMB
Immunogen
FC-tagged full protein expressed in insect cells
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
CTSREVL
Conjugate
eFluor 660
Gene
GPNMB
Gene Alias
Dchil; DC-HIL; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; glycoprotein (transmembrane) nmb; glycoprotein nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; Gpnmb; hematopoietic growth factor inducible neurokinin-1; Hematopoietic growth factor inducible neurokinin-1 type; Hgfin; ipd; iris pigment dispersion; NMB; Osteoactivin; si:ch211-155k24.6; transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB; Unknown (protein for MGC:133733); UNQ1725/PRO9925
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
93695
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- This CTSREVL MAb recognizes human GPNMB also known as Osteoactivin, DC-HIL and HGFIN
- This type-1 transmembrane glycoprotein was described independently as a bone development factor, tumor related molecule, neurokinin, and immune regulator
- Expressed on macrophages and dendritic cells, GPNMB is a ligand for proteoglycan Syndecan-4 (SD-4), which is found on T cells and is known to inhibit their activation and proliferation
- Hence, surface expression of GPNMB by myeloid cells may be indicative of their tolerogenic properties
- Various cancers express GPNMB, and it is suspected to help in immune evasion
- Treatment with IL-10 and various immunosuppressive drugs (e.g., dexamethasone) upregulate GPNMB on macrophages and dendritic cells
- GPNMB may also be secreted
- The CTSREVL antibody will work on paraformaldehyde-fixed cells
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein
- GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines
- GPNMB may be involved in growth delay and reduction of metastatic potential
- Two transcript variants encoding different isoforms have been found for this gene.