IL-17AF Monoclonal Antibody (B8KN8R), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-917-180-Each-of-1 | In Stock | ₹ 16,732.00 |
50-917-180 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,732.00
GST (18%): ₹ 3,011.76
Total Price: ₹ 19,743.76
Antigen
IL-17AF
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q62386, Q7TNI7
Gene Symbols
Il17a, Il17f
Immunogen
Recombinant IL-17AF
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
B8KN8R
Conjugate
eFluor 660
Gene
Il17a
Gene Alias
C87042; CANDF6; Ctla8; CTLA-8; cytokine ML-1; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; Il17a; IL-17A; IL17F; IL-17F; ILN; Interleukin; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17F; interleukin-17A; Interleukin-17F; ML1; ML-1
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16171, 257630
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
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Description
- Description: The B8KN8R monoclonal antibody reacts with mouse interleukin (IL)-17AF heterodimer
- This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers
- IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells
- Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF
- Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis
- Applications Reported: This B8KN8R antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This B8KN8R antibody has been tested by intracellular staining and flow cytometric analysis of Th17-polarized mouse splenocytes after restimulation with Cell stimulation Cocktail plus protein transport inhibitors, using the Intracellular Fixation & Permeabilization Buffer Set (cat
- 88-8824) and protocol
- Please refer to Best Protocls: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resource Tab online
- This can be used at less than or equal to 0.125 μg per test
- IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells
- Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF
- Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.