5377927
CD11c Mouse anti-Human, Brilliant Violet 421, Clone: 3.9, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11c
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Mouse
Target Species
Human, Rhesus Monkey
Immunogen
Human monocytes and synovial cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
3.9
Applications
Flow Cytometry, Immunofluorescence
Conjugate
Brilliant Violet 421
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
ITGAX; AlphaX Integrin; Axb2; Integrin alpha-X; CR4; SLEB6; p150,95 alpha
Related Products
Description
- The 3.9 monoclonal antibody specifically binds to CD11c, which is also known as Integrin alpha X ( α X Integrin/ITGAX), or p150,95 Integrin alpha chain
- CD11c is a ∽150 kDa type I transmembrane glycoprotein
- It is expressed on monocytes, macrophages, granulocytes, NK cells, dendritic cells, and subsets of B and T cells
- It associates with CD18 (Integrin beta 2/ β 2 Integrin) to form the CD11c/CD18 complex, which is also known as p150,95 Integrin, or the Type 4 Complement Receptor (CR4)
- CD11c/CD18 binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1/CD54
- CD11c/CD18 functions as an adhesion molecule that mediates cellular binding to ligands expressed on stimulated epithelium and endothelium
- The 3.9 monoclonal antibody crossreacts with Rhesus macaque leucocytes.