CD27 Ligand/TNFSF7/CD70 Antibody (BU69), Novus Biologicals™

CD27 Ligand/TNFSF7/CD70

0.2 mg/mL

Flow Cytometry, Immunoprecipitation, Immunohistochemistry (Frozen), Immunofluorescence

Unconjugated

Mouse

Apoptosis

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

970

Human WM-1 (Waldenstrom s macroglobulinemia) cell line

Primary

Store at 4C.

30 kDa

BU69

Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunoprecipitation 0.5 - 1 ug/500ug Protein Lysate, Immunohistochemistry-Frozen 0.5 - 1 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml

Monoclonal

Purified

RUO

Human

CD27-L, CD27LCD27 ligand, CD27LG, CD70, CD70 molecule, Ki-24 antigen, surface antigen CD70, TNFSF7CD70 antigen, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7

CD70

IgG1 κ

Protein A or G purified

It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.