CD115 (c-fms) Monoclonal Antibody (AFS98), PE-eFluor™ 610, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 61-115-282-Each-of-1 | In Stock | ₹ 37,291.00 |
61-115-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,291.00
GST (18%): ₹ 6,712.38
Total Price: ₹ 44,003.38
Antigen
CD115 (c-fms)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P09581
Gene Symbols
Csf1r
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12978
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
AFS98
Conjugate
PE-eFluor 610
Gene
Csf1r
Gene Alias
AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
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Description
- The AFS98 MAb reacts with the mouse CD115 molecule, a receptor for macrophage colony stimulating factor (M-CSF) or colony stimulating factor-1 (CSF-1)
- CD115 is expressed by monocyte, macrophage, osteoclast, and some epithelial cells
- It is a 150 kDa c-fms gene product and belongs to immunoglobulin family
- CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage
- CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias
- Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation
- CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases
- Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes
- Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes
- The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction
- Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.