MERTK Monoclonal Antibody (DS5MMER), Super Bright™ 702, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 67-575-182-Each-of-1 | In Stock | ₹ 33,375.00 |
67-575-182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,375.00
GST (18%): ₹ 6,007.50
Total Price: ₹ 39,382.50
Antigen
MERTK
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q60805
Gene Symbols
Mertk
Immunogen
FC-tagged full protein expressed in insect cells
Quantity
100μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
DS5MMER
Conjugate
Super Bright 702
Gene
Mertk
Gene Alias
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17289
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- Description: This JAV4 monoclonal antibody recognizes human V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig
- There are two variants of human VSIG4 that result from alternative splicing
- Isoform 1 is longer and more prevalent than isoform 2, and this JAV4 antibody recognizes both
- VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins
- It contains one complete V-type Ig domain and one truncated C-type Ig domain
- VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages
- It has been shown to bind complement components C3b and iC3b
- This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens
- VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation
- Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion
- Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4
- The JAV4 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized
- This antibody does not cross-react with mouse or rat VSIG4
- Applications Reported: This JAV4 antibody has been reported for use in flow cytometric analysis
- MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease
- Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis)
- Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules
- Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1
- MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
- Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis
- Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.