ATG12-ATG5 Recombinant Rabbit Monoclonal Antibody (20H20L20), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-243-3-Each-of-1 | In Stock | ₹ 53,667.00 |
70-243-3 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,667.00
GST (18%): ₹ 9,660.06
Total Price: ₹ 63,327.06
Antigen
ATG12-ATG5
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O94817, Q2TBJ5, Q3MQ06, Q99J83, Q9CQY1, Q9H1Y0
Gene Symbols
ATG12, ATG5
Immunogen
Peptides corresponding to Human ATG12 (aa 43-57, 122-133)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
20H20L20
Conjugate
Unconjugated
Gene
ATG12
Gene Alias
2010107M05Rik; 3110067M24Rik; 4931423H11Rik; A330058M13Rik; Apg12; Apg12 (autophagy, yeast) homolog; APG12L; APG12-like; APG5; Apg5l; APG5-LIKE; apoptosis-specific protein; ASP; Atg12; ATG12 autophagy related 12 homolog; Atg12l; Atg5; ATG5 autophagy related 5 homolog; Atg5l; Autophagy protein 5; autophagy related 12; autophagy related 5; autophagy-related 12; autophagy-related 5; autophagy-related protein 12; AW319544; C88337; FBR93; HAPG12; hAPG5; Paddy; Ubiquitin-like protein ATG12
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
11793, 361321, 365601, 67526, 9140, 9474
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Monkey, Pig, Cat and Mouse
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells
- It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components
- This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1
- ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy
- This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells
- ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7
- At least two isoforms of ATG12 are known to exist.