TBK1 Recombinant Rabbit Monoclonal Antibody (12H60L39), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-315-4-Each-of-1 | In Stock | ₹ 44,500.00 |
70-315-4 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,500.00
GST (18%): ₹ 8,010.00
Total Price: ₹ 52,510.00
Antigen
TBK1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
Q9UHD2, Q9WUN2
Gene Symbols
TBK1
Immunogen
Peptides corresponding to human TBK1 [1) aa18-aa33, 2) aa563-aa577]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
12H60L39
Conjugate
Unconjugated
Gene
TBK1
Gene Alias
1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
29110, 56480
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Rat, Bovine
- TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling
- TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity
- Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB
- The IKK complex contains IKKa, IKK beta, and IKKK
- A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K
- NAK/TBK1 activates IKK beta through direct phosphorylation
- NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors
- NAK/TBK1 functions upstream of NIK and the IKK complex
- NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.