RNF2 Recombinant Rabbit Monoclonal Antibody (13H1L14), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-325-2-Each-of-1 | In Stock | ₹ 42,720.00 |
70-325-2 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
RNF2
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
Q99496
Gene Symbols
RNF2
Immunogen
Peptides corresponding to human RNF2 [1) aa183-aa201 2) aa155-aa174]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
13H1L14
Conjugate
Unconjugated
Gene
RNF2
Gene Alias
AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; DinG; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; protein DinG; RING 1B; RING 2; RING finger protein 1B; ring finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; Rnf2; wu:fa19h05; wz4556; wz4566
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6045
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Monkey, Mouse, Rat, Pig
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub)
- Therefore, it plays a central role in histone code and gene regulation
- The ligase activity is enhanced by BMI1/PCGF4
- H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals
- RNF2 may be involved in the initiation of both imprinted and random X inactivation
- RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex
- This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development
- The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.