DARC Recombinant Rabbit Monoclonal Antibody (10H52L38), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-370-3-Each-of-1 | In Stock | ₹ 48,950.00 |
70-370-3 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,950.00
GST (18%): ₹ 8,811.00
Total Price: ₹ 57,761.00
Antigen
DARC
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.4
Gene Accession No.
Q16570
Gene Symbols
ACKR1
Immunogen
Protein corresponding to human DARC [aa1-aa63]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
10H52L38
Conjugate
Unconjugated
Gene
ACKR1
Gene Alias
AA162249, ACKR1, Atypical chemokine receptor 1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, CD234 antigen, CTA-134P22.3, DARC, Dfy, Duffy Antigen, Duffy antigen chemokine receptor, Duffy antigen receptor for chemokines, duffy antigen/chemokine receptor, Duffy blood group antigen, duffy blood group chemokine receptor, Duffy blood group, atypical chemokine receptor, Duffy blood group, chemokine receptor, ESTM35, FY, Fy Antigen, Fy glycoprotein, FYDuffy blood group, glycoprotein D, GPD, GPDWBCQ1, GpFy, HGNC:4035, OTTHUMP00000060081, Plasmodium vivax receptor, WBCQ1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2532
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Monkey, Rat, Rabbit
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis
- ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor
- It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines
- ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.