7068191
CD218a (IL-18Ra) Monoclonal Antibody (P3TUNYA), PE, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD218a (IL-18Ra)
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
CD218 antigen-like family member A; CD218a; CDw218a; cytokine receptor; IL1 receptor-related protein; Il18r1; IL-18R1; IL-18R-1; IL18RA; Il18ralpha; IL-18R-alpha; IL18Ralpha2; IL1RRP; IL-1Rrp; IL1R-rp; interleukin 1 receptor related protein; interleukin 18 receptor 1; Interleukin-18; interleukin-18 receptor 1; Interleukin-18 receptor alpha
Gene Symbols
Il18r1
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Il18r1
Clone
P3TUNYA
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q61098
Gene ID (Entrez)
16182
Isotype
IgG2a κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: This P3TUNYA monoclonal antibody reacts with mouse CD218a (Interleukin 18 Receptor alpha)
- CD218a is one of the subunits of the heterodimeric receptor complex for the IL-18 cytokine
- IL-18 is a proinflammatory cytokine and member of the IL-1 family first identified by its role in IFN gamma secretion during toxic shock
- Like the other members of the family, it is synthesized as an inactive precursor which requires cleavage by caspases prior to secretion of the active form
- It is secreted by activated monocytes, macrophages, epithelial cells, and keratinocytes via a non-classical pathway
- IL-18 Receptor is expressed on Th1, but not naive CD4 T cells or Th2, as well as subsets of NK cells and neutrophils
- The heterodimeric receptor is made up of a ligand-binding alpha chain and signal-transducing beta chain
- On its own, IL-18Ra binds IL-18 with low affinity, although the affinity of this interaction increases upon forming a complex with IL-18Rb
- IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in the increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells
- IL-18 has also been found to synergize with IL-23 in the development and function of Th17 cells
- Recently, a subset of CD8 T cells has been discovered that co-secretes IFN gamma with IL-17A and sometimes IL-22
- These Tc17 cells share key transcription factors, chemokine receptors, and cytokine receptors with Th17 cells
- IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family
- This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction
- IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells
- The gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.