CD182 (CXCR2) Monoclonal Antibody (eBio5E8-C7-F10 (5E8-C7-F10)), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD182 (CXCR2)
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD128; CD182; CD182 antigen; CDw128; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; chemokine (C-X-C) receptor 2; Cmkar2; CXC; C-X-C chemokine receptor type 2; CXC motif chemokine; C-X-C motif chemokine receptor 2; Cxcr2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; Gpcr16; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8 receptor alpha chain; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; Il8rb; IL-8rb; IL-8Rh; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B; mIL-8RH
Gene Symbols
CXCR2
Primary or Secondary
Primary
Content And Storage
4° C
Gene
CXCR2
Clone
eBio5E8-C7-F10 (5E8-C7-F10)
Applications
Flow Cytometry
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P25025
Gene ID (Entrez)
3579
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8Rbeta)
- CD182 is a 67-70 kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family
- CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8Ralpha) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes
- Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-alpha, -beta and -gamma, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis
- There are several functional differences between CD181 and CD182
- Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst
- Furthermore, studies have shown that IL-8 predomitly mediates its effects on neutrophil function through CD181
- Applications Reported: This eBio5E8-C7-F10 (5E8-C7-F10) antibody has been reported for use in flow cytometric analysis
- Applications Tested: This eBio5E8-C7-F10 (5E8-C7-F10) antibody has been tested by flow cytometric analysis of normal human peripheral blood
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor
- It is a member of the GPCR family
- Binding of IL-8 to the receptor causes activation of neutrophils
- This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system
- This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity
- It has been reported to be expressed in a wide variety of tissues
- ESTs have been isolated from human placenta and thymus libraries.