Cytokeratin 7 Monoclonal Antibody (LP5K), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Cytokeratin 7
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
CK7; CK-7; Cytokeratin 7; cytokeratin-7; D15Wsu77e; K2C7; K7; Kb7; keratin 7; keratin 7, type II; keratin associated protein 7.1; keratin complex 2, basic, gene 7; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7; keratin, type II cytoskeletal 7; Keratin-7; keratin-associated protein 7-1; keratin-associated protein 7-1-like protein; Krt2-7; KRT7; krt7 {ECO:0000250; LOC100755511; LOC100861181; NACHT, LRR and PYD domains-containing protein 3; sarcolectin; SCL; si:ch73-233m11.1; si:ch73-233m11.2; similar to keratin 7; type II keratin Kb7; type II mesothelial keratin K7; type-II keratin Kb7; UniProtKB:P08729}
Gene Symbols
KRT7
Primary or Secondary
Primary
Content And Storage
4° C
Gene
KRT7
Clone
LP5K
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P08729
Gene ID (Entrez)
3855
Isotype
IgG2b
Purification Method
Affinity chromatography
Product Type
Antibody
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Description
- Description: This LP5K monoclonal antibody reacts with human cytokeratin 7 (K7), a 54-kDa type II (or basic) keratin expressed either alone or paired with cytokeratin 19 in simple epithelia, mesothelium, urothelium, and pseudostratified epithelium
- Expression of cytokeratin 7 in the gastric foveolar, intestinal, and stratified squamous epithelia is extremely low or undetectable
- Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues
- In addition, most carcinomas express cytokeratin 7
- The coordinated expression of this keratin with cytokeratin 20 is commonly used as a diagnostic marker for a variety of carcinomas
- Applications Reported: This LP5K antibody has been reported for use in immunoblotting (WB) and immunocytochemistry (ICC)
- Applications Tested: This LP5K antibody has been tested by immunofluorescent staining of paraformaldehyde fixed and permeabilized cells
- This can be used at less than or equal to 10 μg/mL
- It is recommended that the antibody be titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- Cytokeratin 7 blocks interferon-dependent interphase and stimulates DNA synthesis in cells
- Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).