7092231
Somatostatin Monoclonal Antibody (ICDCLS), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Somatostatin
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
Antrin; Growth hormone release-inhibiting factor; Neuronostatin; NST; preprosomatostatin; prepro-somatostatin; SMST; SOM; Somatostatin; somatostatin 28; somatostatin-14; Somatostatin-28; somatotropin release-inhibiting factor; SRIF; SS; SS-14; SS-28; Sst; SST-14
Gene Symbols
SST
Primary or Secondary
Primary
Content And Storage
4° C
Gene
SST
Clone
ICDCLS
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Rat
Gene Accession No.
P60041, P60042, P61278
Gene ID (Entrez)
20604, 24797, 6750
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin
- Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or somatotrophin release-inhibiting factor (SRIF), is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein
- Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas as well as by the hypothalamus and intestine
- Somatostatin has a variety of functions, such as regulating the endocrine system and affecting neurotransmission and cell proliferation
- Somatostatin also inhibits the release of numerous secondary hormones, such as insulin and glucagon
- Somatostatin can be used to identify medium size aspiny neurons in the striatum, cortex, and hippocampus
- Expression of somatostatin is present in hyperplasia of the pancreatic islets as well as islet cell tumors such as somatostatinomas
- Applications Reported: This ICDCLS antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and microscopy
- Applications Tested: This ICDCLS antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 0.1 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene
- Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors
- This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract
- Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.