7092473
CD206 Mouse anti-Human, APC, Clone: 19.2, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD206
Applications
Flow Cytometry
Conjugate
APC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
Macrophage mannose receptor
Clone
19.2
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Placental Macrophage Mannose Receptor
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The 19.2 monoclonal antibody specifically binds to CD206 which is also known as the macrophage mannose receptor (MMR) or C-type lectin domain family 13 member D (CLEC13D)
- CD206 is a type I transmembrane glycoprotein of approximately 162 kDa which binds to glycoconjugates containing mannose, fucose, or N-acetylglucosamine
- These carbohydrates are present on the surface of many microorganisms and enable the macrophage to bind to microorganisms through the MMR and internalize them during the process of phagocytosis
- CD206 is expressed on human macrophages, endothelial cells, and cultured dendritic cells
- It is not detected on resting monocytes
- Mannose receptor expression is upregulated on peripheral blood mononuclear cells following 3 day incubation with GM-CSF.