7092511
CD279 Hamster anti-Mouse, PE, Clone: J43, BD
Hamster Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD279
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Hamster
Target Species
Mouse
Immunogen
Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
J43
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype
IgG2 κ
Purification Method
Affinity Purified
Description
PD-1
Related Products
Description
- Description The J43 antibody reacts with CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1 gene of the CD28 family of the Ig superfamily
- The expression of Pdcd1 mRNA and PD-1 protein is tightly regulated
- PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells
- In addition, Pdcd1 mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage
- The presence of an ITIM ( I mmunoreceptor nhibitory M otif) on PD-1's intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses
- The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily
- The J43 antibody blocks the binding of PD-1 to its two ligands.