7092512
CD279 Mouse anti-Human, FITC, Clone: MIH4, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD279
Concentration
0.5mg/mL
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human PD-1 Transfected Cell Line
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
MIH4
Applications
Flow Cytometry
Conjugate
FITC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2
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Description
- The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily
- CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells
- Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms
- It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region
- PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family
- Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion
- Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs
- The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.