7092677
CD8 Mouse anti-Human, APC-Cy7, Clone: SK1, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD8
Applications
Flow Cytometry
Conjugate
APC-Cyanine7
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32
Clone
SK1
Classification
Monoclonal
Host Species
Mouse
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Immunogen
Human Peripheral Blood T Cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The SK1 monoclonal antibody specifically binds to CD8 alpha (CD8α)
- CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily
- CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells
- Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β)
- CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers
- CD8 plays important roles in T cell activation and selection
- The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen
- The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling.