7092728
Granzyme B Mouse anti-Human, FITC, Clone: GB11, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Granzyme B
Applications
Flow Cytometry
Conjugate
FITC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Clone
GB11
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Granzyme B
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Description The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa
- Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin
- In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes
- Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis
- Granzyme B may also be involved in the hydrolysis of extracellular matrix components
- Detectable levels of granzyme B have been detected in sera from healthy volunteers
- The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.