CD2 Antibody (UMCD2), Novus Biologicals™

CD2

Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate

Monoclonal

Purified

RUO

Human

P06729

914

Human Thymocytes/Sezary T cells

Primary

Store at 4C.

50 kDa

UMCD2

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation

Unconjugated

Mouse

Adaptive Immunity, Apoptosis, Immunology

PBS with 0.05% BSA. with 0.05% Sodium Azide

CD2 antigen, CD2 antigen (p50), sheep red blood cell receptor, CD2 molecule, Erythrocyte receptor, FLJ46032, LFA-2, LFA-3 receptor, lymphocyte-function antigen-2, Rosette receptor, SRBC, T11, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5

CD2

IgG2a κ

Protein A purified

CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.