CD1b Antibody (RIV12), Novus Biologicals™

CD1b

Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml

Monoclonal

Purified

RUO

Human

P29016

910

Human peripheral lymphocytes

Primary

Store at 4C.

49 kDa

RIV12

Flow Cytometry, Immunocytochemistry, Immunofluorescence

Unconjugated

Mouse

Immunology

PBS with 0.05% BSA. with 0.05% Sodium Azide

CD1, CD1A, CD1b antigen, CD1B antigen, b polypeptide, CD1b molecule, cortical thymocyte antigen CD1B, differentiation antigen CD1-alpha-3, MGC125990, MGC125991, R1, T-cell surface glycoprotein CD1b

CD1B

IgG1 κ

Protein A purified

The mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.