CD21 Antibody (CR2/1952) - Azide and BSA Free, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD21
Concentration
1 mg/mL
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P20023
Gene ID (Entrez)
1380
Immunogen
Recombinant human CR2 (CD21) protein fragment (around aa 44-196) (exact sequence is proprietary)
Primary or Secondary
Primary
Content And Storage
Store at 4°C.
Molecular Weight of Antigen
140 kDa
Clone
CR2/1952
Dilution
Immunohistochemistry-Paraffin 1-2 ug/ml
Classification
Monoclonal
Form
Purified
Research Discipline
Adaptive Immunity, Dendritic Cell Markers, Immunology
Formulation
10mM PBS with No Preservative
Gene Alias
C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
Gene Symbols
CR2
Isotype
IgG1 κ
Purification Method
Protein A or G purified
Test Specificity
Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
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Description
- CD21 Monoclonal specifically detects CD21 in Human samples
- It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.