7144006
CENP-B Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CENP-B
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
Centromere protein B, 80kDa
Gene Symbols
CENPB
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunocytochemistry, Immunofluorescence
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P07199
Gene ID (Entrez)
1059
Immunogen
Between 540 and C-term
Primary or Secondary
Primary
Content And Storage
4° C
Gene
CENPB
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- CENPB is a highly conserved protein that facilitates centromere formation
- It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family
- It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus
- It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation
- It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family
- It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus
- The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA
- This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.