Sin1 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
Sin1
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
JC310, MEKK2-interacting protein 1, MGC2745, MIP1SIN1SIN1b, mitogen-activated protein kinase associated protein 1, Mitogen-activated protein kinase 2-associated protein 1, mSIN1, ras inhibitor MGC2745, SAPK-interacting protein 1, SIN1g, stress-activated protein kinase-interacting 1, stress-activated map kinase interacting protein 1, Stress-activated map kinase-interacting protein 1, target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1
Immunogen
Between 470 and C-term
Primary or Secondary
Primary
Content And Storage
4° C
Gene
MAPKAP1
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
Q8BKH7, Q9BPZ7
Gene ID (Entrez)
227743, 79109
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Turkey, Sheep, Bovine, Dog, Horse, Guinea pig_10141, Pig, Panda, Orangutan, Sin1 was initially identified as the human homolog of S
- pombe SIN1
- Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network
- MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs
- MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones
- Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway
- Multiple alternatively spliced isoforms of MAPKAP1 have been identified.